Our mission is to accelerate the pace of finding cures for childhood cancer by empowering scientists and doctors to harness the power of Big Data. Large-scale collections of harmonized data provide a unique perspective on complex diseases; however, putting such data to use remains challenging. The first informatics lab of its kind, we construct tools that make data and analysis widely available, easily mineable, and broadly reusable. And we train scientists to put these new powers to use.